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  • Bioluminescent imaging of Cdk2 inhibition in vivo 

    Zhang, Guo-Jun; Safran, Michal; Wei, Wenyi; Sorensen, Erik; Lassota, Peter; Zhelev, Nikolai; Neuberg, Donna S.; Shapiro, Geoffrey; Kaelin Jr, William G. (Nature Publishing Group, 2004-05)
    Many proteins and pathways of pharmaceutical interest impinge on ubiquitin ligases or their substrates. The cyclin-dependent kinase (Cdk) inhibitor p27, for example, is polyubiquitylated in a cell cycle−dependent manner ...