Browsing by Author "Mullen, Peter"
Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition Goltsov, Alexey; Faratian, Dana; Langdon, Simon P.; Mullen, Peter; Harrison, David J.; Bown, James L. (Elsevier, 2012-02)Systems biology approaches that combine experimental data and theoretical modelling to understand cellular signalling network dynamics offer a useful platform to investigate the mechanisms of resistance to drug interventions ...
Systems biology reveals new atrategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab Faratian, Dana; Goltsov, Alexey; Lebedeva, Galina; Sorokin, Anatoly; Moodie, Stuart; Mullen, Peter; Kay, Charlene; Um, In Hwa; Langdon, Simon P.; Goryanin, Igor; Harrison, David J. (American Association for Cancer Research, 2009-08-15)Resistance to targeted cancer therapies such as trastuzumab is a frequent clinical problem not solely because of insufficient expression of HER2 receptor but also because of the overriding activation states of cell signaling ...
Tashkandi, Ghassan; Goltsov, Alexey; Mullen, Peter; Bown, James L.; Harrison, David J.; Langdon, Simon P. (American Association for Cancer Research, 2015-07)This is an abstract of a poster presentation presented at AACR Special Conference: Targeting the PI3K-mTOR Network in Cancer; 14-17 September 2014, Philadelphia, Pennsylvania