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  • New lupane derived compounds with pro-apoptotic activity in cancer cells: synthesis and structure−activity relationships 

    Šarek, Jan; Klinot, Jiří; Džubák, Petr; Klinotová, Eva; Nosková, Věra; Křeček, Václav; Kořínková, Gabriela; Thomson, Jean Oliver; Janošťáková, Anna; Wang, Shudong; Parsons, Simon; Fischer, Peter M.; Zhelev, Nikolai Z.; Hajdúch, Marián (American Chemical Society, 2003)
    Cellular screening of various synthetic triterpenoid compounds formally derived from lupane has identified a number of analogues as potential anticancer drug candidates. Here we describe the synthesis and structure−activity ...