Now showing items 11-26 of 26

  • Gene therapy: theoretical and bioethical concepts 

    Smith, Kevin R. (Elsevier Science B.V., Amsterdam, 2003-07)
    Gene therapy holds great promise. Somatic gene therapy has the potential to treat a wide range of disorders, including inherited conditions, cancers, and infectious diseases. Early progress has already been made in the ...
  • Gene transfer in higher animals: theoretical considerations and key concepts 

    Smith, Kevin R. (Elsevier, 2002-10)
    Gene transfer technology provides the ability to genetically manipulate the cells of higher animals. Gene transfer permits both germline and somatic alterations. Such genetic manipulation is the basis for animal transgenesis ...
  • Homeopathy is unscientific and unethical 

    Smith, Kevin R. (Blackwell Publishing, 2012-11)
    In opposition to the premises of Against Homeopathy – a Utilitarian Perspective, all four respondents base their objections on the central claims that homeopathy is in fact scientifically plausible and is supported by ...
  • Human germline genetic modification: a utilitarian bioethical perspective 

    Smith, Kevin R. (Nova Science Publishers Inc, 2005)
  • Human germline genetic modification: scientific and bioethical perspectives 

    Smith, Kevin R.; Chan, Sarah; Harris, John (Elsevier, 2012-10)
    The latest mammalian genetic modification technology offers efficient and reliable targeting of genomic sequences, in the guise of designer genetic recombination tools. These and other improvements in genetic engineering ...
  • Paternal age bioethics 

    Smith, Kevin R. (BMJ Publishing Group, 2015-06-02)
    Modern genetic sequencing studies have confirmed that the sperm of older men contain a greater number of de novo germline mutations than the sperm of younger men. Although most of these mutations are neutral or of minimal ...
  • Problems of affluence in morality 

    Smith, Kevin R. (Philosophy Now, 2002-11)
  • Religion, secular medicine and utilitarianism: a response to Biggar 

    Smith, Kevin R. (BMJ, 2015-06)
    Nigel Biggar has argued that religion ought to be given a seat at the negotiating table of medical ethics. I respond in broadly utilitarian terms, arguing that the flawed empirical basis, lack of rationality and non-universality ...
  • The role of sperm-mediated gene transfer in genome mutation and evolution 

    Smith, Kevin R. (Elsevier Science B.V., Amsterdam, 2002-10)
    Contradictory evidence surrounds the claim that sperm cells are able to introduce exogenous DNA into the oocyte at the time of fertilisation. Although strong natural barriers exist against sperm-mediated gene transfer, ...
  • Sperm cell mediated transgenesis: a review 

    Smith, Kevin R. (Taylor & Francis, 1999)
    Transgenesis would be greatly streamlined if sperm cells could be used as transgene vectors. Attempts to 'force' sperm cells to take up transgenes may be more worthy of further study than 'autouptake' attempts. However, ...
  • Sperm-mediated gene transfer: applications and implications 

    Smith, Kevin R.; Spadafora, Corrado (Wiley-Blackwell, 2005-05)
    Recent developments in studies of sperm-mediated gene transfer (SMGT) now provide solid ground for the notion that sperm cells can act as vectors for exogenous genetic sequences. A substantive body of evidence indicates ...
  • Synthetic biology: a utilitarian perspective 

    Smith, Kevin R. (John Wiley & Sons, 2013-10)
    I examine the positive and negative features of synthetic biology (‘SynBio’) from a utilitarian ethical perspective. The potential beneficial outcomes from SynBio in the context of medicine are substantial; however it is ...
  • Theoretical mechanisms in targeted and random integration of transgene DNA 

    Smith, Kevin R. (INRA/EDP Sciences, 2001-12)
    The genetic manipulation of mammalian cells and animals would be greatly expedited if gene targeting could be reliably achieved in the widest possible range of host cell types. This paper considers empirical evidence and ...
  • The use of genes for performance enhancement: doping or therapy? 

    Oliveira, R. S.; Collares, T. F.; Smith, Kevin R.; Collares, T. V.; Seixas, F. K. (Associação Brasileira de Divulgação Científica, 2011-12)
    Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility ...
  • Why homeopathy is unethical 

    Smith, Kevin R. (Wiley-Blackwell, 2011-09)
  • Word use and semantics in alternative medicine: a survey of editors of medical and related journals 

    Smith, Kevin R.; Sampson, Wallace (Medscape, 2008)
    Objective To investigate the views, practices, and policies of medical journal editors on the use of words and phrases present in altmed manuscripts submitted for publication. Design Postal survey of 56 journals, with ...