Now showing items 1-4 of 4

  • Gene transfer in higher animals: theoretical considerations and key concepts 

    Smith, Kevin R. (Elsevier, 2002-10)
    Gene transfer technology provides the ability to genetically manipulate the cells of higher animals. Gene transfer permits both germline and somatic alterations. Such genetic manipulation is the basis for animal transgenesis ...
  • The role of sperm-mediated gene transfer in genome mutation and evolution 

    Smith, Kevin R. (Elsevier Science B.V., Amsterdam, 2002-10)
    Contradictory evidence surrounds the claim that sperm cells are able to introduce exogenous DNA into the oocyte at the time of fertilisation. Although strong natural barriers exist against sperm-mediated gene transfer, ...
  • Sperm cell mediated transgenesis: a review 

    Smith, Kevin R. (Taylor & Francis, 1999)
    Transgenesis would be greatly streamlined if sperm cells could be used as transgene vectors. Attempts to 'force' sperm cells to take up transgenes may be more worthy of further study than 'autouptake' attempts. However, ...
  • Sperm-mediated gene transfer: applications and implications 

    Smith, Kevin R.; Spadafora, Corrado (Wiley-Blackwell, 2005-05)
    Recent developments in studies of sperm-mediated gene transfer (SMGT) now provide solid ground for the notion that sperm cells can act as vectors for exogenous genetic sequences. A substantive body of evidence indicates ...