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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/1167

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Title: Repair, abort, ignore? Strategies for dealing with UV damage
Authors: Tummala, Hemanth
Khalil, Hilal S.
Zhelev, Nikolai Z.
Affiliation: University of Abertay Dundee. Scottish Informatics, Mathematics, Biology and Statistics Centre
Keywords: UV
DNA damage
DNA repair
Individual repair capacity
Issue Date: Aug-2011
Publisher: Diagnosis Press
Type: Journal Article
Refereed: peer-reviewed
Rights: This is the published version of this article. Reproduced with permission from the publisher. Published version (c)Diagnosis Press, available from http://dx.doi.org/10.5504/bbeq.2011.0079
Citation: Tummala, H., Khalil, H.S. and Zhelev, N. 2011. Repair, abort, ignore? Strategies for dealing with UV damage. Biotechnology and Biotechnological Equipment. 25(3): pp.2443-2446. Available from http://dx.doi.org/10.5504/bbeq.2011.0079
Abstract: DNA repair is a prominent member of the nuclear transactions triad (replication, transcription, and repair). Sophisticated mechanisms govern the cellular process of decision-making (to repair or not to repair, to proceed with cell cycle or not and, eventually, to let the cell survive or die) and the temporal and spatial distribution of the DNA repair activities. UV radiation is a very common and virtually unavoidable mutagen whose carcinogenic potential seems to accumulate over time. Various strategies have been developed to avoid or decrease UV damage to cellular DNA, based on prevention of exposure as well as on post-irradiation measures. It is, however, important to acknowledge that the individual capacity for DNA repair varies during the life of the individual and must, therefore, be assessed so as to determine whether the individual is coping with environmental UV damage. Assessment of individual repair capacity might greatly modify the existing therapeutic strategies for common cancers and ought to become a routine part of health prophylaxis.
URI: http://hdl.handle.net/10373/1167
ISSN: 1310-2818
Appears in Collections:SIMBIOS Collection
Science Engineering & Technology Collection

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