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|Title: ||Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin|
|Authors: ||Wang, Shudong|
Zhelev, Nikolai Z.
Fischer, Peter M.
|Affiliation: ||University of Abertay Dundee. Scottish Informatics, Mathematics, Biology and Statistics Centre|
Cell delivery vector
|Issue Date: ||May-2006|
|Type: ||Journal Article|
|Rights: ||Published version (c)Elsevier, available from http://dx.doi.org/10.1016/j.bmcl.2006.02.035|
|Citation: ||Wang, S., et al. 2006. Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin. Bioorganic and Medicinal Chemistry Letters. 16(10): pp.2628-2631. Available from http://dx.doi.org/10.1016/j.bmcl.2006.02.035|
|Abstract: ||Synthesis of paclitaxel–penetratin (pAntp) constructs, in which the 2′- or 7-position of paclitaxel was used as the attachment site for linker connecting the drug and peptide moieties, is described. Paclitaxel–2′-pAntp[43–58]-NH23b and paclitaxel–2′-pAntp[52–58]-NH23c showed excellent antitumour activity against human lung and breast cancer cell lines. These conjugates were highly soluble and stable with a half-life of >8 h under cell culture conditions. The drug–peptide conjugates may be therapeutically useful due to improved pharmaceutical properties.|
|Appears in Collections:||SIMBIOS Collection|
Science Engineering & Technology Collection
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