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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/1189

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Title: Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin
Authors: Wang, Shudong
Zhelev, Nikolai Z.
Duff, Susan
Fischer, Peter M.
Affiliation: University of Abertay Dundee. Scottish Informatics, Mathematics, Biology and Statistics Centre
Keywords: Paclitaxel
Cell delivery vector
Drug–peptide conjugate
Antitumour activity
Issue Date: May-2006
Publisher: Elsevier
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Elsevier, available from http://dx.doi.org/10.1016/j.bmcl.2006.02.035
Citation: Wang, S., et al. 2006. Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin. Bioorganic and Medicinal Chemistry Letters. 16(10): pp.2628-2631. Available from http://dx.doi.org/10.1016/j.bmcl.2006.02.035
Abstract: Synthesis of paclitaxel–penetratin (pAntp) constructs, in which the 2′- or 7-position of paclitaxel was used as the attachment site for linker connecting the drug and peptide moieties, is described. Paclitaxel–2′-pAntp[43–58]-NH23b and paclitaxel–2′-pAntp[52–58]-NH23c showed excellent antitumour activity against human lung and breast cancer cell lines. These conjugates were highly soluble and stable with a half-life of >8 h under cell culture conditions. The drug–peptide conjugates may be therapeutically useful due to improved pharmaceutical properties.
URI: http://hdl.handle.net/10373/1189
ISSN: 0960-894X
Appears in Collections:SIMBIOS Collection
Science Engineering & Technology Collection

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