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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/1225

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Title: Laser light scattering applications in biotechnology
Authors: Zhelev, Nikolai Z.
Barudov, S.
Affiliation: University of Abertay Dundee. Scottish Informatics, Mathematics, Biology and Statistics Centre
Keywords: Light--Scattering
Biotechnology
Issue Date: Sep-2005
Publisher: Diagnosis Press
Type: Other
Refereed: n/a
Rights: This is the published version of this paper. Reproduced with permission from the publisher. Published version (c)Diagnosis Press, available from http://www.diagnosisp.com/dp/journals/view_article.php?journal_id=1&archive=0&issue_id=7&article_id=218
Citation: Zhelev, N. and Barudov, S. 2005. Laser light scattering applications in biotechnology. Biotechnology & Biotechnological Equipment. 19(3): pp.3-8. Available from http://www.diagnosisp.com/dp/journals/view_article.php?journal_id=1&archive=0&issue_id=7&article_id=218
Abstract: Recent advancement of laser light scattering applications in biotechnology are reviewed with emphasis on their use in the biopharmaceutical industry. Light scattering methods have been used to date to characterize biomolecules in solution. They can provide information about the size and conformation of proteins and their aggregation state as well as their ability to crystallise. In addition, modern light scattering instrumentation is becoming method of choice for studying macromolecular interactions. Interactions between macromolecules such as proteins and nucleic acids mediate fundamental processes and their modulation has led to new strategies for developing therapeutics. Light scattering approaches offer significant advantage to other approaches for studying molecular interactions. Compared with other techniques, light scattering is very quick, uses minimal sample quantities, allows recovery of the sample and does nor require derivatisation.
URI: http://hdl.handle.net/10373/1225
ISSN: 1310-2818
Appears in Collections:SIMBIOS Collection
Science Engineering & Technology Collection

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