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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/1282

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Title: War without weapons: constitution of healthy and pathological phenotypes associated with polymorphisms in genes involved in the maintenance of genome integrity
Authors: Oluwaseun, Omoboye Adebola
Khalil, Hilal S.
Affiliation: University of Abertay Dundee. Scottish Informatics, Mathematics, Biology and Statistics Centre
Keywords: Phenotype
Genomes
Issue Date: Aug-2012
Publisher: Diagnosis Press
Type: Journal Article
Refereed: peer-reviewed
Rights: This is the published version of this article. Reproduced with permission from the publisher. Published version (c)Diagnosis Press, available from http://dx.doi.org/10.5504/bbeq.2012.0053
Citation: Oluwaseun, O.A. and Khalil, H.S. 2012. War without weapons: constitution of healthy and pathological phenotypes associated with polymorphisms in genes involved in the maintenance of genome integrity. Biotechnology and Biotechnological Equipment. 26(4): pp.3073-3078. Available from http://dx.doi.org/10.5504/bbeq.2012.0053
Abstract: Capacity to repair DNA damage may vary significantly between individuals coming out as healthy on routine physical and laboratory examinations. This variance does not generally cause distress or disease unless in case that specific triggers are present, but, taken together with other factors, may increase the risk for certain types of cancer or may modulate the outcome of anticancer therapies. Carriership of certain polymorphic variants in DNA repair genes may also modify the course of the normal process of aging. The present paper reviews the role of some of the common polymorphisms in DNA repair genes and in genes involved in the maintenance of genomic integrity; and their association, separately or in combination, with the ‘healthy’ phenotype and with certain diseases and conditions related to exposure to increased levels of oxidative damage.
URI: http://hdl.handle.net/10373/1282
ISSN: 1310-2818
Appears in Collections:SIMBIOS Collection

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