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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/133

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Title: Gene therapy: the potential applicability of gene transfer technology to the human germline
Authors: Smith, Kevin R.
Affiliation: University of Abertay Dundee. School of Contemporary Sciences
Keywords: Sperm-mediated gene therapy
Gene transfer
Genetic modification
Pronuclear microinjection
Gene targeting
Issue Date: Jun-2004
Publisher: Ivyspring International Publisher
Type: Article
Refereed: peer-reviewed
Rights: © Ivyspring International Publisher. This is an open access article. Distribution or copying is permitted, provided that the article is in whole, unmodified, and properly cited.
Citation: Smith KR. Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline. Int J Med Sci 2004; 1:76-91. Available from http://www.medsci.org/v01p0076.htm
Abstract: The theoretical possibility of applying gene transfer methodologies to the human germline is explored. Transgenic methods for genetically manipulating embryos may in principle be applied to humans. In particular, microinjection of retroviral vector appears to hold the greatest promise, with transgenic primates already obtained from this approach. Sperm-mediated gene transfer offers potentially the easiest route to the human germline, however the requisite methodology is presently underdeveloped. Nuclear transfer (cloning) offers an alternative approach to germline genetic modification, however there are major health concerns associated with current nuclear transfer methods. It is concluded that human germline gene therapy remains for all practical purposes a future possibility that must await significant and important advances in gene transfer technology.
URI: http://hdl.handle.net/10373/133
ISSN: 1449-1907
Appears in Collections:Science Engineering & Technology Collection

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