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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/235

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Title: Genetic, ophthalmic, morphometric and histopathological analysis of the Retinopathy Globe Enlarged (rge) chicken
Authors: Inglehearn, Chris F.
Morrice, David R.
Lester, Douglas H.
Robertson, Graeme W.
Mohamed, Moin D.
Simmons, Ian
Downey, Louise M.
Thaung, Caroline
Bridges, Leslie R.
Paton, Ian R.
Smith, Jacqueline
Petersen-Jones, Simon
Hocking, Paul M.
Burt, David W.
Affiliation: University of Abertay Dundee. School of Social and Health Sciences
Keywords: Chickens
Issue Date: 1-Jul-2003
Publisher: Emory University
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Emory University, available from http://www.molvis.org/molvis/v9/a41/
Citation: Inglehearn, C. F., et al. 2003. Genetic, ophthalmic, morphometric and histopathological analysis of the Retinopathy Globe Enlarged (rge) chicken. Molecular Vision. 9: pp.295-300. [Online] Available from: http://www.molvis.org/molvis/v9/a41/
Abstract: Purpose: To identify the locus responsible for rge (retinopathy globe enlarged) in chickens and further characterise the rge phenotype. Methods: A colony of chickens carrying the rge mutation was rederived from a single heterozygous animal of the original line. The eyes of blind, heterozygous and normal birds were subjected to ophthalmic, morphometric and histopathological examination to confirm and extend published observations. DNA samples were obtained and subjected to a whole genome linkage search. Results: From 138 classified backcross progeny, 56 birds were blind and 82 sighted. Heterozygous birds were indistinguishable from wild type, but homozygotes had sluggish or unresponsive pupils, posterior sub-capsular lens opacities and an atrophic pecten. The fundus appeared normal with no significant pigmentary disturbance, but axial length and eye weight were increased. Pathology revealed focal retinal lesions. Linkage analysis placed the rge locus in a small region of chicken chromosome 1. Conclusions: rge is a severe recessive retinal dystrophy in chickens, with associated globe enlargement. Linkage mapping has highlighted chicken chromosome 1 in a region most probably homologous to human chromosomes 7q31-35, 21q21 or 22q12-21. Candidate disease loci include RP10 (IMPDH1) and uncharacterised Ushers (USH1E) and glaucoma (GLC1F) loci.
URI: http://hdl.handle.net/10373/235
ISSN: 1090-0535
Appears in Collections:Social & Health Sciences Collection

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