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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/249

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Title: The role of sperm-mediated gene transfer in genome mutation and evolution
Authors: Smith, Kevin R.
Affiliation: University of Abertay Dundee. School of Social and Health Sciences
Keywords: Genetic transformation
Issue Date: Oct-2002
Publisher: Elsevier Science B.V., Amsterdam
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Elsevier Science B.V., Amsterdam, available from DOI: 10.1016/S0306-9877(02)00150-0
Citation: Smith, K. R. 2002. The role of sperm-mediated gene transfer in genome mutation and evolution. Medical Hypotheses. 59(4): pp.433-437. [Online] Available from: DOI: 10.1016/S0306-9877(02)00150-0
Abstract: Contradictory evidence surrounds the claim that sperm cells are able to introduce exogenous DNA into the oocyte at the time of fertilisation. Although strong natural barriers exist against sperm-mediated gene transfer, such barriers are unlikely to be absolutely inviolable. If sperm cells can act as vectors for exogenous DNA, it follows that the genome of sexually reproducing animals may be subject to alteration by exogenous DNA sequences carried by sperm cells. At present there are insufficient data to permit quantification of the rate of sperm-mediated gene transfer. The implications of sperm-mediated gene transfer are significant and include evolutionary effects on the mammalian genome and pathologies in humans from de novo mutations. Despite the absence of firm data, geneticists would be wise to be vigilant to the potential consequences of sperm-mediated gene transfer.
URI: http://hdl.handle.net/10373/249
ISSN: 0306-9877
Appears in Collections:Social & Health Sciences Collection

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