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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/368

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Title: Pseudomonas aeruginosa PAO1 resistance to zinc pyrithione: phenotypic changes suggest the involvement of efflux pumps
Authors: Abdel Malek, Suzanne M.
Al-Adham, Ibrahim S.
Matalka, Khalid Z.
Collier, Phillip J.
Affiliation: University of Abertay Dundee. School of Contemporary Sciences
Keywords: Pseudomonas aeruginosa
Issue Date: Aug-2009
Publisher: Springer Verlag
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Springer Verlag, available from DOI: 10.1007/s00284-009-9396-9
Citation: Abdel Malek, S. M., et al. 2009. Pseudomonas aeruginosa PAO1 resistance to zinc pyrithione: phenotypic changes suggest the involvement of efflux pumps. Current Microbiology. 59(2): pp.95-100. Available from: DOI: 10.1007/s00284-009-9396-9
Abstract: The aim of this study is to investigate the involvement of an efflux pump in the development of Pseudomonas aeruginosa resistance to zinc pyrithione (ZnPT). In the presence of efflux inhibitor carbonyl cyanide m-chlorophenyl-hydrazone (CCCP), the minimum inhibitory concentration of ZnPT for P. aeruginosa resistant cells is reduced significantly (p < 0.05). In addition, the concentration of ZnPT excluded by the resistant bacteria was reduced significantly (p < 0.01). However, the above reductions did not reach the levels measured for P. aeruginosa PAO1 sensitive strain. Furthermore, such changes in P. aeruginosa resistant cells were correlated with the overexpression of outer membrane proteins, reduced sensitivity toward imipenem (p < 0.01) and increased sensitivity toward sulphatriad and chloramphenicol (p < 0.05). In a continuation to a previous study, we conclude that P. aeruginosa resistance to ZnPT is multifactorial and involves induced efflux systems.
URI: http://hdl.handle.net/10373/368
ISSN: 1432-0991
Appears in Collections:Science Engineering & Technology Collection

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