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Title: Induction of a heat shock-type response in fission yeast following nitrogen starvation
Authors: Walker, Graeme M.
McWilliams, Philip G
Affiliation: University of Abertay Dundee. School of Contemporary Sciences
Keywords: Schizosacchromyces pombe
Nitrogen saturation
Heat shock
Issue Date: 1989
Publisher: Wiley-Blackwell
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Wiley-Blackwell, available from doi:10.1002/yea.320050607
Citation: Walker, G.M. and McWilliams, P.G. 1989. Induction of a heat shock-type response in fission yeast following nitrogen starvation. Yeast. 5(6): pp. 477 - 486. Available from: doi: 10.1002/yea.320050607
Abstract: When cells of the fission yeast, Schizosaccharomyces pombe, are incubated in medium devoid of a nitrogen source, they accelerate into cell division and differentially synthesize two polypeptides at 46 and 27 kD (named p46 and p27) after a delay of about an hour. The synthesis of p46 and p27 is transient. These proteins have no obvious cell cycle connection since they are also evident in nitrogen-starved (but not accelerated) cells of the temperature-sensitive mutant of S. pombe, wee 1·50h-. We infer from this that p46 and p27 are synthesized as a direct result of nutritional stress. The possibility that p46 and p27 represent examples of general environmental stress proteins was investigated by comparing nitrogen starvation with the heat-shock response in S. pombe. Heat-shock analysis of cells revealed the existence of two proteins of similar Mr to p46 and p27. In addition, nitrogen-starved cells acquired thermotolerance in a manner similar to heat-shocking cells. We suggest that nitrogen starvation in fission yeast induces a subset of the total array of heat-shock proteins.
URI: http://hdl.handle.net/10373/468
ISSN: 0749-503X
Appears in Collections:Science Engineering & Technology Collection

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