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|Title: ||Magnesium and the regulation of germ-tube formation in candida albicans|
|Authors: ||Walker, Graeme M.|
Sullivan, Patrick A.
Shepherd, Maxwell G.
|Affiliation: ||University of Abertay Dundee. School of Contemporary Sciences|
|Issue Date: ||1984|
|Publisher: ||Society for General Microbiology.|
|Type: ||Journal Article|
|Rights: ||Published version (c)Society for General Microbiology is available from:doi: 10.1099/00221287-130-8-1941|
|Citation: ||Walker, GM., Sullivan, P.A., and Shepherd, M.G. 1984. Magnesium and the regulation of germ-tube formation in candida albicans. Journal of General Microbiology. 130(8): pp.1941-1945. Available from: doi:10.1099/00221287-130-8-1941|
|Abstract: ||Candida albicans requires Mg2+ for germ-tube formation. Mg-deficient media, metal ion chelators and the ionophore A23187 inhibited germ-tube formation. Cell Mg content during exponential yeast-phase growth remained constant but increased throughout germ-tube formation. The onset of germ-tube formation coincided with a sharp peak in Mg concentration within the cells. Yeast-phase cells of strain CA2, which did not form germ-tubes, had a lower Mg content and failed to accumulate Mg when incubated under conditions for germ-tube formation. Mg also increased the uptake and incorporation of N-acetylglucosamine. These findings point to a central regulatory role for Mg in C. albicans morphogenesis.|
|Appears in Collections:||Science Engineering & Technology Collection|
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