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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/475

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Title: Magnesium and the regulation of germ-tube formation in candida albicans
Authors: Walker, Graeme M.
Sullivan, Patrick A.
Shepherd, Maxwell G.
Affiliation: University of Abertay Dundee. School of Contemporary Sciences
Keywords: GlcNAc
N-acetylglucosamine
Issue Date: 1984
Publisher: Society for General Microbiology.
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Society for General Microbiology is available from:doi: 10.1099/00221287-130-8-1941
Citation: Walker, GM., Sullivan, P.A., and Shepherd, M.G. 1984. Magnesium and the regulation of germ-tube formation in candida albicans. Journal of General Microbiology. 130(8): pp.1941-1945. Available from: doi:10.1099/00221287-130-8-1941
Abstract: Candida albicans requires Mg2+ for germ-tube formation. Mg-deficient media, metal ion chelators and the ionophore A23187 inhibited germ-tube formation. Cell Mg content during exponential yeast-phase growth remained constant but increased throughout germ-tube formation. The onset of germ-tube formation coincided with a sharp peak in Mg concentration within the cells. Yeast-phase cells of strain CA2, which did not form germ-tubes, had a lower Mg content and failed to accumulate Mg when incubated under conditions for germ-tube formation. Mg also increased the uptake and incorporation of N-acetylglucosamine. These findings point to a central regulatory role for Mg in C. albicans morphogenesis.
URI: http://hdl.handle.net/10373/475
ISSN: 0738-8551
Appears in Collections:Science Engineering & Technology Collection

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