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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/488

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Title: An investigation into the potential use of chelating agents and antibiotics as synchrony inducers in the fission yeast schizosaccharomyces pombe
Authors: Walker, Graeme M.
Duffus, John H.
Affiliation: University of Abertay Dundee. School of Contemporary Sciences
Keywords: Fission yeast
Schizosaccharomyces
Issue Date: 1979
Publisher: Society for General Microbiology.
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Society for General Microbiology, avalable from doi: 10.1099/00221287-114-2-391
Citation: Walker, G.M. and Duffus, J.H. 1979. An investigation into the potential use of chelating agents and antibiotics as synchrony inducers in the fission yeast schizosaccharomyces pombe. Journal of General Microbiology. 114(2): pp.391-400. [Online] Available from doi: 10.1099/00221287-114-2-391
Abstract: Following the discoveries that the divalent cation ionophore A23187 and the divalent cation chelating agent EDTA can be used to synchronize yeast cell division, a study has been undertaken of the possible use of other chelating agents and antibiotics which interact with divalent cations in controlling cell division in the fission yeast Schizosaccharomyces pombe. All the agents studied (five chelators and two antibiotics) arrested cell division in growing cultures of this yeast, but only sodium pyrophosphate and citrate induced synchrony of cell division. Novobiocin produced a transient inhibition of cell division, treated cells exhibiting "endogenous recovery" in the continued presence of the antibiotic. The results obtained are discussed in relation to the hypothesis that the concentration of intracellular Mg2+ regulates cell division.
URI: http://hdl.handle.net/10373/488
ISSN: 0022-1287
Appears in Collections:Science Engineering & Technology Collection

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