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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/727

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Title: Magnesium and cell cycle control: an update.
Authors: Walker, Graeme M.
Affiliation: University of Abertay Dundee. School of Contemporary Sciences
Keywords: Cell cycle
Cell division
Cell transformation
Issue Date: 1986
Publisher: Karger
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)Karger, available from http://www.ncbi.nlm.nih.gov/pubmed/3515058
Citation: Walker, G.M. 1986. Magnesium and cell cycle control: an update. Magnesium. 5(1):9-23 . Available from http://www.ncbi.nlm.nih.gov/pubmed/3515058
Abstract: Accumulating evidence, from bacteria to human cells, points to a universal role for magnesium in controlling the cell cycle. In microorganisms, the co-ordinate sequence of events which culminate in biomass doubling and cell division may be modulated through expression of differential magnesium effects during the cell cycle. For example, it has been suggested in bacteria that growth and cell division may possess different affinities for magnesium; whilst in yeast, cell cycle-dependent fluxes in intracellular magnesium are postulated to regulate cell proliferation. In mammalian cells, magnesium is important in governing key rate-limiting steps in the cell cycle, particularly at the onset of DNA synthesis and at mitosis. Furthermore, it has been demonstrated that cell transformation may cause selective loss of this regulatory role for magnesium, implying that magnesium is important in oncogenesis and perhaps in the expression of malignancy.
URI: http://hdl.handle.net/10373/727
ISSN: 0252-1156
Appears in Collections:Science Engineering & Technology Collection

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