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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/803

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Title: Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation
Authors: Zhang, H.
Zhu, Jiujiang
Garratt, C. J.
Holden, A. V.
Affiliation: University of Abertay Dundee. School of Computing & Engineering Systems
Keywords: Bioelectric potentials
Biomembrane transport
Blood vessels
Cardiovascular system
Diseases
Partial differential equations
Reaction-diffusion systems
Issue Date: Sep-2004
Publisher: Institute of Electrical and Electronics Engineers
Type: Conference Paper
Refereed: peer-reviewed
Rights: Published version (c)Institute of Electrical and Electronics Engineers, available from http://dx.doi.org/10.1109/CIC.2004.1442891
Citation: Zhang, H., et al. 2004. Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. Computers in Cardiology, 2004. 31: pp.141-144. Available from http://dx.doi.org/10.1109/CIC.2004.1442891
Abstract: Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.
URI: http://hdl.handle.net/10373/803
ISBN: 0780389271
ISSN: 0276-6574
Appears in Collections:Computing & Engineering Systems Collection

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