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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/807

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Title: Cellular modelling of electrical remodelling in two different models of human atrial myocytes
Authors: Zhang, H.
Zhu, Jiujiang
Garratt, C. J.
Holden, A. V.
Affiliation: University of Abertay Dundee. School of Computing & Engineering Systems
Keywords: Bioelectric potentials
Biomembrane transport
Cellular biophysics
Physiological models
Issue Date: Sep-2003
Publisher: Institute of Electrical and Electronics Engineers
Type: Conference Paper
Refereed: peer-reviewed
Rights: Published version (c)Institute of Electrical and Electronics Engineers, available from http://dx.doi.org/10.1109/CIC.2003.1291272
Citation: Zhang, H., et al. 2003. Cellular modelling of electrical remodelling in two different models of human atrial myocytes. Computers in Cardiology, 2003. 30: pp.777-780. Available from http://dx.doi.org/10.1109/CIC.2003.1291272
Abstract: Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.
URI: http://hdl.handle.net/10373/807
ISSN: 0276-6574
Appears in Collections:Computing & Engineering Systems Collection

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