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Please use this identifier to cite or link to this item: http://hdl.handle.net/10373/923

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Title: Theoretical mechanisms in targeted and random integration of transgene DNA
Authors: Smith, Kevin R.
Affiliation: University of Abertay Dundee. School of Contemporary Sciences
Keywords: Transgenesis
Gene targeting
Gene therapy
Integration
Homologous recombination
Concatenation
Issue Date: Dec-2001
Publisher: INRA/EDP Sciences
Type: Journal Article
Refereed: peer-reviewed
Rights: Published version (c)INRA/EDP Sciences, available from http://dx.doi.org/10.1051/rnd:2001102
Citation: Smith, K.R. 2001. Theoretical mechanisms in targeted and random integration of transgene DNA. Reproduction Nutrition Development. 41(6): pp.465-485. Available from http://dx.doi.org/10.1051/rnd:2001102
Abstract: The genetic manipulation of mammalian cells and animals would be greatly expedited if gene targeting could be reliably achieved in the widest possible range of host cell types. This paper considers empirical evidence and theoretical considerations associated with transgene integration, and concludes that utilisation of gene targeting in non-selective systems awaits further progress in modelling homologous recombination.
URI: http://hdl.handle.net/10373/923
ISSN: 0926-5287
Appears in Collections:Science Engineering & Technology Collection

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